Effects of Brucellaphage on Extracellular and Intracellular Brucella abortus.

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Abstract
Interactions between brucellaphage and Brucella abortus were studied under extracellular conditions, and also when the bacteria resided intracellularly within guinea pig mononuclear phagocytes maintained in vitro. Inhibitory effects of untreated or UV-treated phage on the multiplication of brucellae were observed both in the extra- and intracellular environments. Heat-treated phage failed to produce these effects. These findings suggest an association between brucellacidal, and possibly brucellastatic, effects and phage protein. It was demonstrated that the effects on intracellular bacteria occurred when monocytes containing brucellae were exposed to phage.

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