Resolution of chronic hypoxemia in pediatric sickle cell patients after treatment with hydroxyurea
- 21 February 2008
- journal article
- case report
- Published by Wiley in Pediatric Blood & Cancer
- Vol. 50 (6) , 1258-1260
- https://doi.org/10.1002/pbc.21480
Abstract
Chronic hypoxemia is a common manifestation among patients with sickle cell anemia (SCA) who develop chronic lung disease. We report the beneficial effect of hydroxyurea on chronic hypoxemia in three pediatric patients with SCA and recurrent episodes of acute chest syndrome (ACS). All three patients improved rapidly after they were treated with hydroxyurea despite having additional risk factors for hypoxemia. A prospective trial is warranted to assess whether there is a therapeutic effect from the use of hydroxyurea in pediatric SCA patients with chronic hypoxemia. Pediatr Blood Cancer 2008;50:1258–1260.Keywords
This publication has 12 references indexed in Scilit:
- Clinical correlates of steady‐state oxyhaemoglobin desaturation in children who have sickle cell diseaseBritish Journal of Haematology, 2005
- Chronic sickle cell lung disease: new insights into the diagnosis, pathogenesis and treatment of pulmonary hypertensionBritish Journal of Haematology, 2005
- Chronic Transfusion Therapy for Children With Sickle Cell Disease and Recurrent Acute Chest SyndromeJournal of Pediatric Hematology/Oncology, 2005
- Asthma in children with sickle cell disease and its association with acute chest syndromeThorax, 2005
- Nitric oxide production from hydroxyureaFree Radical Biology & Medicine, 2004
- Impact of chronic transfusion on incidence of pain and acute chest syndrome during the Stroke Prevention Trial (STOP) in sickle-cell anemiaThe Journal of Pediatrics, 2001
- Prevalence and reversibility of lower airway obstruction in children with sickle cell diseaseThe Journal of Pediatrics, 2001
- Effect of Hydroxyurea on the Frequency of Painful Crises in Sickle Cell AnemiaNew England Journal of Medicine, 1995
- Pulse oximetry and factors associated with hemoglobin oxygen desaturation in children with sickle cell diseaseBlood, 1993
- Sleep related upper airway obstruction and hypoxaemia in sickle cell disease.Archives of Disease in Childhood, 1992