Shape Change and the Percentage of Sialic Acid Removed by Neuraminidase from Human Platelets

Abstract
The sialic acid of human gel-filtered platelets was studied before and after ADP-induced shape change. Neuraminidase [from Clostridium perfringens and Vibrio cholerae] cleaved 47% of the total sialic acid from discoid control platelets and platelets that had become spiny spheres after treatment with 5 .mu.M ADP.