Aggregation studies in crystals of apolar helical peptides: Boc‐Aib‐Val‐Ala‐Leu‐Aib‐Val‐Ala‐Leu‐Aib‐OMe
- 1 December 1988
- journal article
- research article
- Published by Wiley in International Journal of Peptide and Protein Research
- Vol. 32 (6) , 536-543
- https://doi.org/10.1111/j.1399-3011.1988.tb01385.x
Abstract
In the crystal, the backbone of Boc-(Aib-Val-Ala-Leu)2-Aib-OMe adopts a helical form with four .alpha.-type hydrogen bonds in the middle, flanked by 310-type hydrogen bonds at either end. The helical molecules stack in columns with head-to-tail hydrogen bonds, either directly between NH and CO, or bridged by solvent molecules. The packing of the helices is parallel, even in space group P21. Cell parameters are a = 0.837(2) .ANG., b = 15.565(3) .ANG., c = 20.087(5) .ANG., .beta. = 96.42(2).degree., dcalc = 1.091 g/cm3 for C46H83N9O12 .cntdot. 1.5H2O .cntdot. 0.67CH3OH. There appears to be some hydration of the backbone in this apolar helix.Keywords
This publication has 7 references indexed in Scilit:
- Monoclinic polymorph of Boc‐Trp‐Ile‐Ala‐Aib‐Ile‐Val‐Aib‐Leu‐Aib‐Pro‐OMe(anhydrous)International Journal of Peptide and Protein Research, 1988
- Aqueous channels within apolar peptide aggregates: solvated helix of the alpha-aminoisobutyric acid (Aib)-containing peptide Boc-(Aib-Ala-Leu)3-Aib-OMe.2H2O.CH3OH in crystals.Proceedings of the National Academy of Sciences, 1988
- Conformation of a 16-residue zervamicin IIA analog peptide containing three different structural features: 3(10)-helix, alpha-helix, and beta-bend ribbon.Proceedings of the National Academy of Sciences, 1987
- Parallel packing of alpha-helices in crystals of the zervamicin IIA analog Boc-Trp-Ile-Ala-Aib-Ile-Val-Aib-Leu-Aib-Pro-OMe.2H2O.Proceedings of the National Academy of Sciences, 1986
- Structures of eleven zervamicin and two emerimicin peptide antibiotics studied by fast atom bombardment mass spectrometryJournal of the American Chemical Society, 1981
- Partial structural information combined with the tangent formula for noncentrosymmetric crystalsActa Crystallographica Section B: Structural Science, Crystal Engineering and Materials, 1968
- A theory of phase determination for the four types of non-centrosymmetric space groups 1P222, 2P22, 3P12, 3P22Acta Crystallographica, 1956