Frontal lobotomy and the elimination of conditioned anxiety in the rat.

Abstract
Twenty experimental and 20 control rats were conditioned to display anxiety (crouching and immobility) in an electrified grillbox. The experimental animals were then subjected to cerebral frontal lobotomy, and the control animals to a sham operation. Upon retesting for anxiety, it was discovered that the experimental animals displayed fewer of the responses indicative of anxiety than did the controls; differences were significant well beyond the .01% level of confidence. The common notion that lobotomy tends to abolish anxiety thus receives considerable support.

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