Inhibition of Bilirubin Conjugation in vitro.

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Abstract
The possible role of synkavite and chemo-therapeutic agents in jaudice production in the newborn period was studied. The amount of conjugated bilirubin produced in a given incubation of rat liver extract and homogenate was determined both with and without the competing substrates. Synkavite produced inhibition at concentrations which might be expected in an infant, particularly from high doses. Chloromycetin (chloramphenicol) showed slight inhibition within the accepted range and streptomycin just beyond the accepted range of serum levels. Penicillin G, tetracycline, erythromycin, Gantrisin (sulfafurazole), and hydrocortisone showed essentially no inhibition.

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