GENTISIC ACID - A NEW STABILIZER FOR LOW TIN SKELETAL IMAGING AGENTS - CONCISE COMMUNICATION

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  • 1 January 1980
    • journal article
    • research article
    • Vol. 21  (4) , 366-370
Abstract
In vitro stabilization of low-Sn bone-imaging agents was previously achieved with ascorbic acid. Gentisic acid is an equally effective antioxidant for the (1-hydroxyethylidene) diphosphonate (HEDP) and hydroxymethylenediphosphonate (HMDP) skeletal agents. In vitro studies show < 2% free sodium [99mTc] pertechnetate at 24 h with the gentisic acid stabilizer. In guinea pigs at 3 and 24 h, with 14C- or 3H-labeled gentisic acid as stabilizer, no alteration occurs in the biodistribution of skeletal imaging agent by the addition of the gentisic acid. Gentisic acid is a safe and effective stabilizer with a bioequivalency with ascorbic acid.