The Host Cell Chaperone Hsp90 Is Necessary for Cytotoxic Action of the Binary Iota-Like Toxins
Open Access
- 1 May 2004
- journal article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 72 (5) , 3066-3068
- https://doi.org/10.1128/iai.72.5.3066-3068.2004
Abstract
The heat shock protein Hsp90 is essential for uptake of the binary actin ADP-ribosylating toxins Clostridium perfringens iota-toxin and Clostridium difficile transferase into eukaryotic cells. Inhibition of Hsp90 by its specific inhibitor radicicol delayed intoxication of Vero cells by these toxins. A common Hsp90-dependent mechanism for their translocation is discussed.Keywords
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