Clinical and Neuropathological Features of the Arctic APP Gene Mutation Causing Early-Onset Alzheimer Disease
Open Access
- 1 April 2008
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Neurology
- Vol. 65 (4) , 499-505
- https://doi.org/10.1001/archneur.65.4.499
Abstract
Alzheimer disease (AD), the most common neurodegenerative disorder, is neuropathologically characterized by extracellular deposition of β-amyloid peptide (Aβ) into plaques and intraneuronal accumulation of abnormal tau protein as neurofibrillary tangles.Keywords
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