Urea Metabolism in Sulfate-Deprived and Sulfate-Supplemented Rats

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Abstract
The influence of sulfate-deprivation and supplementation on urea excretion, in vitro synthesis of urea as well as the response of the rat to high-protein stress was studied. Sulfate-deprivation resulted in a significant decrease in urea excretion during the fourth and seventh weeks. During this time there were no differences in fecal nitrogen excretion but there were significant decreases in urinary nitrogen levels which suggested retention of nitrogen. Because there were no significant differences in weight gains between the two diet groups, the observed retention of nitrogen was probably transient, perhaps as glutamine or a similar urea precursor. Decreased urea excretion during the critical times appeared to be due to a lack of capacity of the sulfate-deprived animal to synthesize urea as measured indirectly by the inability of sulfate-deprived animals to respond as readily to high-protein challenge or directly in an in vitro system. An hypothesis was presented to explain these findings. Copyright © 1971. American Society of Animal Science . Copyright 1971 by American Society of Animal Science.

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