ALTERATIONS OF PROTEIN, NUCLEIC ACIDS AND ENZYME ACTIVITIES IN THE HUMAN ENDOMETRIUM DURING THE NORMAL MENSTRUAL CYCLE

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Abstract
In twenty-one women with a normal menstrual cycle determinations of protein, of nucleic acids and of some enzymes of energy metabolism have been performed on endometrial tissue. The calculation of enzyme activities is based on the DNA content which represents a biochemical parameter of the cell number. The glucose-6-phosphate dehydrogenase and the fructose-1,6-diphosphate aldolase show markedly increased activities during the secretory phase of the cycle. This suggests that the ovarian hormones induce a considerable stimulation of carbohydrate metabolism of the endometrial cells. Isocitrate dehydrogenase activity shows a transient but marked increase immediately after ovulation. There is also activation of an amino peptidase during the secretory phase of the cycle. The data presented are compatible with previous observations on the cyclic variations of these parameters in the rat uterus.

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