Stereochemical studies. Part 30. Synthesis and conformational analysis of deca- and dodeca-hydropyrido[2,1-b]quinazolin-11-ones
- 1 January 1979
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 7,p. 1765-1769
- https://doi.org/10.1039/p19790001765
Abstract
cis- and trans- Decahydro- and dodecahydro-pyrido[2,1-b]quinazolin-11-ones have been synthesized and their preferred conformations established by 1H n.m.r. spectroscopy. At room temperature the A and B rings of the cis-decahydro derivatives are conformationally mobile, while the t-butyl derivatives have fixed conformations. The predominant conformation of the cis-dodecahydro-derivatives is that in which the CO group is equatorial, the N atom is axial, and the configuration of the nitrogen bridgehead B/C fusion is trans.This publication has 0 references indexed in Scilit: