STUDIES ON ANTIGEN-INDUCED ARTHRITIS IN MICE .3. CELL AND SERUM TRANSFER EXPERIMENTS

  • 1 January 1977
    • journal article
    • research article
    • Vol. 118  (5) , 1645-1648
Abstract
Antigen-induced arthritis in mice occurs after immunization and subsequent intraarticular challenge with methylated bovine serum albumin (mBSA). In adoptive transfer experiments, susceptible C57BL mice and resistant CBA mice were compared in their capacity to express delayed-type hypersensitivity (DTH) by ear assay, and to express arthritis. The expression of DTH could be transferred incrementally by lymphoid cells in C57BL mice, but not in CBA mice. Immune lymphoid cells and, to a much lesser extent, serum transferred the capacity to develop arthritis in C57BL mice. The reactivity of transferred cells was abolished by anti-Thy-1 serum but enhanced by enrichment for T[thymus-derived]-cells with anti-immunoglobulin columns. If this model disease can be equated with human rheumatoid synovitis, the lesions in the human disease would be an expression of a T cell-dependent activity.