EPI Imaging of Global Increase of Brain MR Signal with Breath‐hold Preceded by Breathing O2
- 1 March 1995
- journal article
- research article
- Published by Wiley in Magnetic Resonance in Medicine
- Vol. 33 (3) , 448-452
- https://doi.org/10.1002/mrm.1910330322
Abstract
Brain MR signal has been observed to decrease during cessation of breathing due to the increase of deoxyhemoglobin in the blood. However, for both animal and human studies, we have demonstrated that if the subjects breathed 100% oxygen in advance of apnea for a short time, T2*‐weighted MR brain signal increased when breathing was stopped for a period of 30–60 s. This demonstrates the possibility of measuring responses to hemodynamic change throughout the entire brain with a single respiratory perturbation in a rapid, reliable, and robust manner.Keywords
This publication has 10 references indexed in Scilit:
- Functional MRI of CO2 induced increase in cerebral perfusionNMR in Biomedicine, 1994
- Measurement of regional blood oxygenation and cerebral hemodynamicsMagnetic Resonance in Medicine, 1993
- Echo‐planar MR imaging of human brain oxygenation changesJournal of Magnetic Resonance Imaging, 1993
- Functional brain mapping by blood oxygenation level-dependent contrast magnetic resonance imaging. A comparison of signal characteristics with a biophysical modelBiophysical Journal, 1993
- Intrinsic signal changes accompanying sensory stimulation: functional brain mapping with magnetic resonance imaging.Proceedings of the National Academy of Sciences, 1992
- Dynamic magnetic resonance imaging of human brain activity during primary sensory stimulation.Proceedings of the National Academy of Sciences, 1992
- Time course EPI of human brain function during task activationMagnetic Resonance in Medicine, 1992
- Echo‐planar time course MRI of cat brain oxygenation changesMagnetic Resonance in Medicine, 1991
- Brain magnetic resonance imaging with contrast dependent on blood oxygenation.Proceedings of the National Academy of Sciences, 1990
- The Effects of Changes in Pa CO 2 Cerebral Blood Volume, Blood Flow, and Vascular Mean Transit TimeStroke, 1974