Changes in the ovary of the mouse following exposure to X-rays.—Part III. Irradiation of the non-parous adult

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Abstract
The ovaries of a series of mice X-rayed at weaning time (3 weeks old) were described in the first part (1) of this series of papers, and of a series X-rayed at or before birth in the second part (2). The œstrous cycles of these animals were dealt with elsewhere (Parkes (4, 5)). In almost all animals normal cestrous cycles were maintained, although the ovaries were devoid of follicles and, in most cases, of corpora lutea. Histological study led us to conclude that following irradiation:— (1) All the oocytes degenerated completely, and that the cells of the membrana granulosa, and of the theca interna, in follicles where it was differentiated, subsequently followed their example. In some cases the follicles did not degenerate, but grew and formed corpora lutea atretica. These persisted but had no effect on the cycle.

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