Mechanism of Incorporation of Fluoride into Bone Salt

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Abstract
Bone salt was equilibrated with serum salt solutions and allowed to exchange with radioactive calcium or phosphate until a state of equilibrium was reached. When dissolved fluoride was added to the equilibration solutions most of the fluoride was removed from solution and the amounts and specific activities of dissolved calcium and phosphate were decreased. The decrease in specific activity was due to solution of unexchanged bone salt. When fluoride was added in amounts less than 3 ppm, the amounts of dissolved calcium and phosphate dissolved plus the decreased level in solution were about equal to the amounts required for the precipitation of fluorapatite. Precipitation of fluoride as fluorapatite on bone-salt surfaces appears to be an important mechanism for removal of small amounts of fluoride from dilute salt solutions.