In Vivo Activation of Zoxazolamine Metabolism by Flavone
- 25 June 1982
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 216 (4553) , 1419-1421
- https://doi.org/10.1126/science.7089530
Abstract
The metabolism of zoxazolamine to 6-hydroxyzoxazolamine by liver microsomes from neonatal rats is stimulated severalfold by the in vitro addition of flavone, a naturally occurring compound found in several plant species. The intraperitoneal injection of flavone into neonatal rats causes an immediate severalfold stimulation in the rate of total body metabolism of simultaneously administered zoxazolamine. This is the first demonstration of stimulation of oxidative drug metabolism in vivo by a xenobiotic that is an activator of hepatic microsomal monooxygenases in vitro.This publication has 20 references indexed in Scilit:
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