THE CARCINOGENIC EFFECT OF A PAPILLOMA VIRUS ON THE TARRED SKIN OF RABBITS

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Abstract
The Shope papilloma virus when injected intraven. into the tarred ears of rabbits gave rise to papiliomas at the site of tarring. Destructive growths, behaving like carcinomas, followed. They extended to the lymph and blood vessels, and in one case, to a lymph node. The virus, incubated with cancer extract and injected intraven., decreased the pathogenicity of the virus, producing only papillomas of the usual type. On incubation of virus and cancer extract heated to destroy its inhibitory effect, injection caused growths which behaved like carcinomas. In tarred but uninoculated rabbits or animals in which the virus failed to localize in the ears, malignant growths appeared only rarely. The more abundant the localization of virus, the greater the amt. of malignant growths demonstrable. The malignant growths exhibited the histological features typical of carcinomas. It was proved that the malignant growths were actual carcinomas by their morphology and manifestation of independent activity.