Some Effects of a Hemicholinium Compound (HC-3) on Neuromuscular Transmission in the Cat
- 1 December 1962
- journal article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 14 (Supplement) , 34T-36T
- https://doi.org/10.1111/j.2042-7158.1962.tb10525.x
Abstract
The hemicholinium compound 4, 4′-biphenylylenebis[carbonylmethyl-(2-hydroxyethyl)dimethylammonium bromide] (HC-3) (Long and Schueler, 1954) has been shown to produce a neuromuscular block in rabbits which is of gradual onset, long duration (Reitzel and Long, 1959) and dependent on the frequency of nerve stimulation (Wilson and Long, 1959). An attempt has been made in the present study to determine the effect of HC-3 on neuromuscular transmission in the cat by using the tibialis anterior muscle-sciatic nerve preparation. Some effects on this preparation have already been described by Bowman and Rand (1961).Keywords
This publication has 1 reference indexed in Scilit:
- A New Series of Cholinesterase Inhibitors*Journal of the American Pharmaceutical Association (Scientific ed.), 1954