Production of the Generalized Shwartzman Reaction by Activated Hageman Factor and α-Adrenergic Stimulation

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Abstract
Summary: Infusion of activated purified Hageman factor and norepinephrine into pregnant rats produces renal glomerular capillary thrombosis identical to the generalized Shwartzman reaction. Activated Hageman factor alone, norepinephrine alone, and inosithin (a substitute for platelet phospholipid) alone, in addition to the combination of inosithin and norepinephrine were incapable of causing the reaction. These studies confirm the evidence that four basic components of the reaction are 1. activation of Hageman factor, 2. platelet phospholipid, 3. ‘‘fibrinolysin inhibition’’, and 4. stimulation of α-adrenergic receptor sites.
Funding Information
  • National Institutes of Health, United States Public Health Service. (Grant HE-12033-03)

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