Permeability of the Round Window Membrane to Middle-Sized Molecules in Purulent Otitis Media
- 1 January 1990
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA Otolaryngology–Head & Neck Surgery
- Vol. 116 (1) , 57-60
- https://doi.org/10.1001/archotol.1990.01870010061018
Abstract
• The effect of pneumococcal otitis media on the permeability of the round window membrane was evaluated using tetraethylammonium ions as a tracer. Round window membrane permeability is reduced significantly at resolved stages of purulent otitis media. In contrast, measurements of round window membrane permeability indicate that acute purulent otitis media has a tendency to facilitate such permeability. Moreover, histologic observations of the round window membrane following bacterial inoculation further support the evidence of functional changes in round window membrane permeability. These findings indicate that the round window membrane in resolved stages of purulent otitis media plays a protective role in preventing the penetration of harmful substances into the inner ear. (Arch Otolaryngol Head Neck Surg. 1990;116:57-60)This publication has 8 references indexed in Scilit:
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- Round window membrane permeability to human serum albumin in antigen-induced otitis mediaAmerican Journal of Otolaryngology, 1988
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