STUDIES ON BIOSYNTHESIS OF CARBOHYDRATE FRAGMENT OF RUBOMYCIN

  • 1 January 1976
    • journal article
    • research article
    • Vol. 21  (4) , 299-301
Abstract
When the rubomycin-producing organism [Actinomyces coeruleorubidus] was grown in the presence of an evenly labeled 14C-glucose and various non-labeled C sources, the carbohydrate part of the antibiotic also became evenly labeled. The activity of the C-1 atom of rubomycin sugar grown against the background of non-labeled glycerol was almost 3 times higher than the respective value of the aglycone activity. 14C-acetate, 14C-propionate, 14C-methionine and daunosamine were not incorporated. There was no splitting of the glucose C skeleton during conversion of glucose into amino sugar.

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