Time course of nigrostriatal degeneration in parkinson's disease

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Abstract
It could be shown that the post mortem analysis of biogenic amines, precursors, and metabolites in the human brain are influenced by various parameters. The patient's medical history; long term observation of the course of the disease; age; sex. Terminal illness; duration of terminal illness. Previous treatment with drugs; last drugs. Time interval between last drug treatment and death; time of day and date of last drug consumption. Rapidity of death; time of death; duration of coma. Changes occurring in tissues before death; patient's constitution during terminal illness. Changes in concentration of the biogenic amines, precursors, and metabolites depending on the patient's age. Time between death and necropsy. Dissection of specimen. Period of storage; temperature of storage. Chronobiological rhythm of substances. Methods of assay. Homogeneity of all mentioned parameters in the control group and patient group. For the first time it could be demonstrated that the time course of nigrostriatal degeneration, independent of the age of the parkinsonian at the beginning of the illness, is linear for the last stage and the denervation progressively increases as the duration of illness progresses.

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