DELETION OF LONG ARM OF CHROMOSOME-20 [DEL(20)(Q11)] IN MYELOID DISORDERS

1 January 1978

journal article
research article

Vol. 52 (5) , 868-877

Abstract

Detailed clinical and cytogenetic studies were performed in 5 patients who had abnormal hematopoiesis and an acquired deletion of an F-group chromosome. Cytogenetic analyses, with banding techniques, of cells from bone marrow, spleen or unstimulated peripheral blood showed a partial deletion of the long arm of chromosome 20 [del(20)(q11)] in all 5 patients. Three patients had myeloproliferative disorders of uncertain classification, the 4th had possible preleukemia and the 5 had acute myelomonocytic leukemia. Although the 5 cases showed certain similarities, the clinical and hematologic findings seen with the 20q- abnormality were not specific. None of the patients showed evidence of polycythemia vera or idiopathic acquired refractory sideroblastic anemia, 2 diseases previously associated with the 20q-. The 20q- abnormality is apparently not limited to diseases primarily affecting erythropoiesis but it can be found in the broader spectrum of myeloid disorders. In polycythemia vera, the 20q- was sometimes regarded as a possible result of previous therapy with cytotoxic agents; but 4 of our patients were untreated when the deletion was 1st noted.

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