Sustained release of drugs from ethylcellulose microcapsules containing drugs dispersed in matrices.
- 1 January 1980
- journal article
- research article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 28 (9) , 2816-2819
- https://doi.org/10.1248/cpb.28.2816
Abstract
The use of ethycellulose microcapsules possessing a reservoir system to achieve sustained release of the antibacterial drug sulfamethizole or [the antineoplastic drug] 5-fluorouracil was examined in vitro. First, the drugs were dispersed in cellulose acetate matrices and then the matrices were microencapsulated using coacervation-phase separation of ethylcellulose from diethylether solution by nonsolvent addition. The surfaces of microcapsules were rounded, but the milled matrices were sharp-edged. In microcapsules of both drugs, longer release half-lives were obtained than with the corresponding matrices.This publication has 2 references indexed in Scilit:
- Release characteristics of dibucaine dispersed in konjac gelsJournal of Biomedical Materials Research, 1979
- Degradation rates of oral resorbable implants (polylactates and polyglycolates): Rate modification with changes in PLA/PGA copolymer ratiosJournal of Biomedical Materials Research, 1977