Susceptibility of Yersinia enterocolitica to eight β-lactam antibiotics and clavulanic acid

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Abstract
Eighty-three strains of Yersinia enterocolitica were studied against benzylpenicillin, ampicillin, carbenicillin, cephalothin, cefamandole, cefoxitin, cefoperazone, cefotaxime and clavulanic acid. The concentrations of these antimicrobials that inhibited 90% of the strains were 128, 32, ≥256, ≥256, 4, 16, 4, ≤0·125, and 100 mg/l, respectively. The addition of 1, 5 or 10 mg/l of clavulanic acid to benzylpenicillin had no effect on Y. enterocolitica, but when 1 mg/l of clavulanic acid was added to ampicillin the MIC dropped up to fourfold. Higher concentrations of clavulanic acid (5 and 10 mg/l) did not result in proportional reductions of ampicillin MICs.

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