Jaundice after Therapy with Chlordiazepoxide Hydrochloride

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Abstract
THE toxic effects of a number of drugs on liver-cell function have been recognized for many years. The magnitude of the problem of drug-induced jaundice is impossible to assess accurately since many cases go unrecognized or unreported. However, a recent review has shown that the number of drugs causing liver dysfunction has nearly doubled since 1959.1,2 Chlordiazepoxide hydrochloride (Librium), a psychotherapeutic agent, was introduced in 1960. One year later, a relation between this drug and hepatic injury was suggested by Cacioppo and Merlis.3 Hollister et al.4 reported elevated serum glutamic oxalacetic transaminase (SGOT) activity in 4 of 36 patients receiving . . .

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