Contributions to ecological chemistry CXIV fate of 2, 2'‐dichlorobiphenyl‐14C in rats upon long‐term feeding1

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Abstract
Each of five male and five female rats was orally dosed with 49.2 μg 2,2'‐dichlorobiphenyl‐ 14C daily for 42 days. After 36 days, the radioactivity in the body reached a plateau level, and male rats had excreted 84.5% of the applied radioactivity, females 87.9%; the residues in most organs were below 0.2 mg/kg. The daily excreted radioactivity after 50 days had decreased to 0.7% (males) and 0.5% (females) of the daily dose; the total excretion was then 86.2% (males) and 89.4% (females) of the total applied dose, and the organs contained % of the radioactivity in the excreta was due to metabolites (one monomethoxy‐, three monohydroxy‐, three dihydroxy‐, one trihydroxy‐2,2'‐dichlorobiphenyl, conjugates, and a dechlorinated derivative).