Effects of Long-Term Alcohol Administration on the Development of Fatty Cirrhosis in Choline-Deficient Rats

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Abstract
Administration of alcohol in the drinking water (15% solution by volume) for 5–6 months was conducted to elucidate how the progression of cirrhosis in choline-deficient rats would be modified by alcohol. In the choline-deficient groups, 90% of rats in the nonalcohol groups showed cirrhosis during 6 months, while no rats of the alcohol-treated group showed severe fibrosis or cirrhosis during 5 months, indicating that simultaneous administration of alcohol retarded the development of choline deficient cirrhosis. And higher serum glutamic oxalacetic transaminase activities and more globular bodies in the liver were observed in the alcohol-treated group than in the nonalcohol group. These results suggested that choline deficiency and alcohol may induce hepatic lesions through a different, atleast in part, mechanism.

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