Streptozotocin-induced diabetes reduces the density of [125I]-endothelin-binding sites in rat cardiac membranes
Open Access
- 1 August 1989
- journal article
- research article
- Published by Wiley in British Journal of Pharmacology
- Vol. 97 (4) , 993-995
- https://doi.org/10.1111/j.1476-5381.1989.tb12552.x
Abstract
The effect of acute, streptozotocin-induced diabetes on the affinity (KD), density (Bmax) and selectivity of specific, high affinity binding sites for [125I]-endothelin ([125I]-ET) in rat cardiac membrane fragments was determined. Three days after a single i.v. bolus dose of streptozotocin (60 mg kg−1), the density of [125I]-ET binding sites was reduced (P < 0.01) without changes in affinity or selectivity.This publication has 17 references indexed in Scilit:
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