Trace elements in cerebrospinal fluid in motor neurone disease.
- 16 June 1984
- Vol. 288 (6433) , 1791-1792
- https://doi.org/10.1136/bmj.288.6433.1791
Abstract
Concentrations of sodium, chlorine, potassium, chromium, iron, cobalt, zinc, rubidium, silver, caesium, and selenium in cerebrospinal fluid from 14 control subjects and 20 patients with motor neurone disease were measured by in vitro neutron activation analysis. No statistically significant correlation was found between the concentrations of any two elements other than sodium and chlorine in either the patient or control group (r = 0.9905; p less than 0.001). The mean cobalt concentration was significantly lower in the patients (p = 0.0015). No other statistically significant difference was shown. The relevance of this finding was examined in relation to current concepts of the pathogenesis of motor neurone disease and the role of cobalt in cellular metabolism.This publication has 3 references indexed in Scilit:
- A New Hypothesis of the Etiology of Amyotrophic Lateral SclerosisArchives of Neurology, 1982
- Muscle metals in motor neuron diseaseAnnals of Neurology, 1980
- Metals in spinal cord tissue of patients dying of motor neuron diseaseAnnals of Neurology, 1979