Neuroanatomical Correlates of Morphine Dependence
- 18 August 1972
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 177 (4049) , 616-617
- https://doi.org/10.1126/science.177.4049.616
Abstract
Naloxone hydrochloride, an opioid antagonist, was applied to several discrete brain regions of morphine-dependent rats to precipitate abstinence. Severe withdrawal signs were elicited after administration in the thalamus but not in neocortical, hippocampal, hypothalamic, or tegmental areas of the brain.Keywords
This publication has 10 references indexed in Scilit:
- Effects of narcotic analgesics and antagonists on the in vivo release of acetylcholine from the cerebral cortex of the catBritish Journal of Pharmacology, 1971
- Formulation of a Morphine Implantation Pellet Suitable for Tolerance-Physical Dependence Studies in MiceJournal of Pharmaceutical Sciences, 1970
- Intracranial Drug Implants: An Autoradiographic Analysis of DiffusionScience, 1969
- THE ASCENDING CHOLINERGIC RETICULAR SYSTEM: NEOCORTICAL, OLFACTORY AND SUBCORTICAL PROJECTIONSBrain, 1967
- Effect of medial thalamic lesions in responses elicited by tooth pulp stimulationAmerican Journal of Physiology-Legacy Content, 1966
- Approach‐avoidance analysis of rat diencephalonJournal of Comparative Neurology, 1963
- Factors regulating oral consumption of an opioid (etonitazene) by morphine-addicted ratsPsychopharmacology, 1963
- Direct adrenergic and cholinergic stimulation of hypothalamic mechanismsAmerican Journal of Physiology-Legacy Content, 1962
- THE ACTION OF MORPHINE AND RELATED SUBSTANCES ON CONTRACTION AND ON ACETYLCHOLINE OUTPUT OF COAXIALLY STIMULATED GUINEA‐PIG ILEUMBritish Journal of Pharmacology and Chemotherapy, 1957
- Central reticular path to intralaminar and reticular nuclei of thalamus for activating EEG related to consciousnessElectroencephalography and Clinical Neurophysiology, 1956