Conformational analysis of 3,4-dimethyltetrahydro-1,3,4-oxadiazine

Abstract
Contrary to a recent report, the diequatorial conformation makes no appreciable contribution to the title compound. Evidence is presented that the preferred conformation is 3-axial-4-equatorial. The activation parameters or the conformational process in this compound are: ΔH 13.25 ± 0.14 kcal mol–1, ΔS+2.8 ± 0.6 cal mol–1 K–1, possibly owing to slowing of a nitrogen inversion process.

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