Effect of using heat-inactivated serum with the Abbott human T-cell lymphotropic virus type III antibody test
- 1 February 1986
- journal article
- research article
- Published by American Society for Microbiology in Journal of Clinical Microbiology
- Vol. 23 (2) , 381-382
- https://doi.org/10.1128/jcm.23.2.381-382.1986
Abstract
The Abbott enzyme immunoassay (Abbott Laboratories, North Chicago, Ill.) for human T-cell lymphotropic virus type III (HTLV-III) antibody was evaluated to determine the effect of using heat-inactivated (56 degrees C for 30 min) serum as the sample. Each of 58 nonreactive serum samples gave a higher A492 value when tested after heat inactivation. Ten of the samples became reactive after heating. Heat-inactivated serum should not be used in the current Abbott HTLV-III antibody test, because this can cause false-positive results.This publication has 5 references indexed in Scilit:
- Thermal inactivation of the acquired immunodeficiency syndrome virus, human T lymphotropic virus-III/lymphadenopathy-associated virus, with special reference to antihemophilic factor.Journal of Clinical Investigation, 1985
- Risk of Nosocomial Infection with Human T-Cell Lymphotropic Virus III (HTLV-III)New England Journal of Medicine, 1985
- Antibodies Reactive with Human T-Lymphotropic Retroviruses (HTLV-III) in the Serum of Patients with AIDSScience, 1984
- Acquired Immunodeficiency Syndrome (AIDS) Associated with TransfusionsNew England Journal of Medicine, 1984
- AIDS—Safety Practices for Clinical and Research LaboratoriesInfection Control, 1984