Acute Staphylococcal Enterocolitis Complicating Oral Neomycin Therapy in Cirrhosis

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Abstract
THE oral administration of certain poorly absorbed antibiotics is widely accepted as an important measure in the management of the neuropsychiatric complications of severe liver disease. Of these anti-bacterial agents, neomycin has proved the most satisfactory, effectively suppressing intestinal flora with a minimum of undesirable or harmful side effects.1 2 3 Although diarrhea,1 steatorrhea,4 occasional systemic absorption of the drug5 , 6 and mild monilial superinfection2 have occurred in a few cases, to our knowledge no serious complications due to neomycin-resistant organisms have been reported to follow the use of this drug in the treatment of impending or overt hepatic coma.Recently, however, we . . .