Cholera stool bacteria repress chemotaxis to increase infectivity

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Abstract
Summary: Factors that enhance the transmission of pathogens are poorly understood. We show that Vibrio cholerae shed in human ‘rice‐water’ stools have a 10‐fold lower oral infectious dose in an animal model than in vitro grown V. cholerae, which may aid in transmission during outbreaks. Furthermore, we identify a bacterial factor contributing to this enhanced infectivity: The achievement of a transient motile but chemotaxis‐defective state upon shedding from humans. Rice‐water stool V. cholerae have reduced levels of CheW‐1, which is essential for chemotaxis, and were consequently shown to have a chemotaxis defect when tested in capillary assays. Through mutational analyses, such a state is known to enhance the infectivity of V. cholerae. This is the first report of a pathogen altering its chemotactic state in response to human infection in order to enhance its transmission.