Cx-Reactive Protein Response in Rabbits during Immunization with Foreign Proteins
Open Access
- 1 July 1960
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Immunology
- Vol. 85 (1) , 72-77
- https://doi.org/10.4049/jimmunol.85.1.72
Abstract
Summary: Primary immunization of rabbits with intravenous bovine serum albumin or human γ-globulin resulted in a biphasic Cx-protein response. The secondary response was attributed to the formation of antigen-antibody complexes in the vascular system, since Cx-protein responses could be elicited by intravenous injection of soluble antigen-antibody complexes, and by formation of complexes in vivo by passive transfer of homologous antibody followed by antigen. A secondary Cx-protein response did not occur following primary intravenous immunization with tobacco mosaic virus, an antigen which disappeared from the blood stream well ahead of the appearance of antibody.Keywords
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