EFFECT OF CORYNEBACTERIUM-PARVUM ON PROLIFERATIVE RATE OF GRANULOCYTE-MACROPHAGE PROGENITOR CELLS AND TOXICITY OF CHEMOTHERAPY

  • 1 January 1978
    • journal article
    • research article
    • Vol. 38  (9) , 2666-2672
Abstract
The interaction of C. parvum [Propionibacterium acnes] and a variety of cell cycle-specific and cell cycle-nonspecific chemotherapeutic agents on granulocytemacrophage progenitor cells [colony-forming units culture (CFU-c)] was studied in C57BL/6 mice. In vitro 3H-thymidine suicide studies showed an increased rate or proliferation of bone marrow CFU-c 24 h after C. parvum injection. In vivo toxicity of cell cycle-specific agents but not of cell cycle-nonspecific agents for bone marrow CFU-c was increased 24 h after C. parvum injections. The increased numbers of CFU-c in the spleen, induced by C. parvum, were also sensitive to a cell cycle-specific agent for up to 7 days after C. parvum injection. Differenences in the kinetics of proliferation of splenic compared to bone marrow CFU-c are suggested. The relative time of administration of chemotherapy and immunostimulants such as C. parvum will have to be carefully considered in the design of clinical trials.