PATHOLOGICAL MECHANISMS TO EXPLAIN SOME CASES OF AMENORRHOEA WITHOUT ORGANIC DISEASE
- 1 April 1975
- journal article
- Published by Wiley in BJOG: An International Journal of Obstetrics and Gynaecology
- Vol. 82 (4) , 337-340
- https://doi.org/10.1111/j.1471-0528.1975.tb00645.x
Abstract
Summary: A test is described to define the site of the lesion causing amenorrhoea in women of child‐bearing age who have normal ovaries and a normal response to luteinizing hormone‐releasing hormone (LH‐RH). Patients able to produce a release of LH following the administration of 1 mg. of oestradiol benzoate (EB) have normal hypothalamic function and thus the site of the defect must lie more centrally in the brain. Patients unable to show these LH surges have either a primary or econdary abnormality affecting their hypothalamic oestrogen “receptor” mechanism or their ability to produce LH‐RH.Keywords
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