Vitamin B12 levels in the prolonged use of sodium nitroprusside

1 March 1984

journal article
research article
Published by Wolters Kluwer Health in Critical Care Medicine

Vol. 12 (3) , 161-163
https://doi.org/10.1097/00003246-198403000-00002

Abstract

Long-term (> 48 h) sodium nitroprusside (SNP) infusion significantly reduced cobalamin (vitamin B₁₂) levels in 23 patients treated in a CCU after myocardial infarction. There was no evidence of vitamin B₁₂ deficiency or SNP toxicity. Low vitamin B₁₂ levels should not limit the use of SNP, because prolonged infusion of SNP at maximum doses of 2.5 μg/kg·min did not adversely affect hemodynamic stability.

Keywords

SODIUM
PROLONGED
NITROPRUSSIDE
B12 LEVELS
VITAMIN
ΜG/KG
COBALAMIN
CCU
INFARCTION

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