Dicentric Ph1 Chromosome
- 1 December 1973
- journal article
- research article
- Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute
- Vol. 51 (6) , 2009-2012
- https://doi.org/10.1093/jnci/51.6.2009
Abstract
Five cases in our chronic myelogenous leukemia series were originally categorized as Ph1-positive and later developed another variant of the Ph1 chromosome. With the new Giemsa banding technique, it appeared to be a dicentric Ph I chromosome. This chromosome was first noted 23 months after diagnosis, with the latest appearance at 57 months. Survival in 3 of the 5 patients after the appearance of the dicentric Ph1 chromosome was 6, 16, and 35 months; the other 2 are still alive.Keywords
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