Live, Attenuated Measles Vaccine

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Abstract
SINCE the earliest reports1, 2appeared in the literature describing anaphylaxis and death, as well as minor reactions, to egg protein, physicians have become increasingly aware of the potency of egg protein as an antigen in human atopic disease. These and subsequent reports3, 5have included reactions not only from ingestion but also especially from injection of egg protein, as contained in egg skin-testing preparations and in viral vaccines produced by culture of live virus in chick embryo. The studies have shown that less than 1% of a random sample of "normal" children have positive skin tests to egg protein, whereas positive skin tests are found in about 20% of allergic children. In a general population of allergic children, 5% are believed to be clinically allergic to egg and will show varying reactions upon ingestion of whole egg. It was also shown and reported by several observers that such children and adults are more likely to

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