Studies of the Ligand Binding to Cholera Toxin, II. The hydrophilic moiety of sialoglycolipids
- 1 January 1977
- journal article
- research article
- Published by Walter de Gruyter GmbH in Hoppe-Seyler´s Zeitschrift Für Physiologische Chemie
- Vol. 358 (1) , 159-164
- https://doi.org/10.1515/bchm2.1977.358.1.159
Abstract
The binding between cholera toxin or its B-protein subunit and various ganglioside-related oligosaccharides was studied by equilibrium displacement dialysis. At low concentrations of ligand, the binding of monosialo-gangliotetraitol exceeded that of the parent ganglioside II3NeuAc-GgOse4-Cer, the possible cell surface receptor for the toxin. The terminal galactose residue and an intact carboxyl group of the sialic acid moiety of monosialo-gangliotetraose were apparently necessary for strong binding to the toxin.This publication has 6 references indexed in Scilit:
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