Reflex tracheal gland secretion evoked by stimulation of bronchial C-fibers in dogs
- 1 October 1982
- journal article
- research article
- Published by American Physiological Society in Journal of Applied Physiology
- Vol. 53 (4) , 985-991
- https://doi.org/10.1152/jappl.1982.53.4.985
Abstract
We examined the effect of stimulating bronchial C-fibers on tracheal submucosal gland secretion in anesthetized dogs with open chest and lungs ventilated through the lower trachea. We opened the upper trachea in the midline, retracted the cut edges, and sprayed powdered tantalum onto the exposed mucosa. Secretions from the ducts of submucosal glands caused elevations (hillocks) in the tantalum layer, which were viewed through a microscope and recorded on videotape with a television camera. We counted the hillocks (greater than 0.2 mm diam) in an area of mucosa (1.2 cm2) before and after injecting capsaicin (3 micrograms) into a bronchial artery to stimulate bronchial C-fibers. In the minute before capsaicin was injected 7 +/- 2 (mean +/- SE; n = 20) hillocks appeared and in the minute after 40 +/- 2 hillocks. Bradykinin (1.5 micrograms) had similar effects. Secretion was accompanied by contraction of the trachealis muscle. Effects were abolished by cooling (0 degree C) or cutting the vagus nerves. Since capsaicin and bradykinin stimulate bronchial C-fibers selectively when injected in these small doses, we conclude that bronchial C-fibers furnish the afferent arm of an airway secretory reflex.This publication has 12 references indexed in Scilit:
- Reflex tracheal contraction induced by stimulation of bronchial C-fibers in dogsJournal of Applied Physiology, 1981
- Physiological and pharmacological properties of canine trachealis muscle in vivoJournal of Applied Physiology, 1980
- Bradykinin stimulates afferent vagal C-fibers in intrapulmonary airways of dogsJournal of Applied Physiology, 1980
- MICROPIPET MEASUREMENT OF AIRWAY SUB-MUCOSAL GLAND SECRETION - LARYNGEAL REFLEXPublished by Elsevier ,1980
- Impulse activity in afferent vagal C-fibres with endings in the intrapulmonary airways of dogsRespiration Physiology, 1977
- The effects of irritation at various levels of the airway upon tracheal mucus secretion in the cat.The Journal of Physiology, 1976
- Pulmonary afferent fibres of small diameter stimulated by capsaicin and by hyperinflation of the lungs.The Journal of Physiology, 1965
- Role of the pulmonary arterial baroreceptors in the effects produced by capsaicin in the dogThe Journal of Physiology, 1964
- REFLEX CONTROL OF AIRWAY SIZE*Annals of the New York Academy of Sciences, 1963
- THE PATHOLOGY OF ASTHMA, WITH SPECIAL REFERENCE TO CHANGES IN THE BRONCHIAL MUCOSAJournal of Clinical Pathology, 1960