Abnormal Leucocyte Sodium Transport in Chinese Patients with Essential Hypertension and their Normotensive Offsprings

Publisher Website
Google Scholar
Abstract
Changes in intracellular electrolytes and the rate constant of 22Na efflux from isolated leukocytes in Chinese patients with essential hypertension and their normotensive offspring were studied. The hypertension had an increase of Na content and a reduction of the total or ouabain-sentive 22Na efflux from leukocytes. The normotensives born of hypertensive parents showed lower Na content, K content and reduced rate constant of ouabain-insensitive 22Na efflux from leukocytes. The inhibition of cell Na pump activity may be a marker of essential hypertension. Abnormal cell Na transport observed in normotensives with family history of hypertension may have some etiological linking with the inheritance of hypertension.