A Study of the Use of Clonidine and Naltrexone in the Treatment of Opioid Addiction in the Former USSR

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Abstract
Sixty-eight opioid addicts in Moscow voluntarily entered a two phase study that employed the medications clonidine and naltrexone to withdraw addicts from narcotics and naltrexone for mainenance therpay. Of the 44 subjects entering the withdrawal phase, only 3 completed the procedure and entered naltrexone mainenance. All 27 subjects entering naltrexone maintenance left within 50 days against medical advice. Follow-up on about 75% of the subjects in both phases of the study showed they relapsed to opioid use after leaving treatment.

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