Human Pancreatic Polypeptide: Studies in Fasting and in the Growth Hormone Deficient State

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Abstract
Human pancreatic polypeptide (hPP) was measured in 8 normal subjects and 6 growth hormone deficient dwarfs after insulin-induced hypoglycemia. hPP concentrations increased similarly in both groups with induction of hypoglycemia. In 8 normal subjects fasted for 72 h, no significant elevation of hPP occurred. This is contrary to a previous report indicating such a relationship. Despite the rationale that hPP might play a role in the metabolism of fasting and that its secretion might be altered by growth hormone, no evidence for these relationships could be documented in man.

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