A typical clinical and histologic case of so-called Pagetoid reticulosis or Woringer-Kolopp disease is reported. This is a chronic human cutaneous condition usually with a single focus or a few patches confined to a circumscribed region. A disseminated form was described as Dupont-Vandaele type, but its relationship to classic Woringer-Kolopp disease is uncertain. The nosological location of Pagetoid reticulosis was not established, but there are reasons to regard it as a particular and well-defined entity. In relation to the nature of this condition and the origin of the Pagetoid cells, it is tempting to consider the possibility that Woringer-Kolopp disease might be a lymphoproliferative epidermotropic disorder, classifiable as a benign form of cutaneous T[thymus-derived]-cell lymphoma, but the early histologic changes are rather indicative of epidermal origin.