PRODUCTION OF OVULATION IN HYPOPHYSECTOMIZED RATS

Publisher Website
Google Scholar
Abstract
In the intact rat the intrinsic action of gonadotrophic substances is often complicated by the action of the endogenous gonadotrophins of the test animal. Evidence of such complications is provided by histological differences between the condition of the ovaries of intact and hypophysectomized immature rats when subjected to stimulation by each of a variety of different gonadotrophic substances [Noble, Rowlands, Warwick & Williams, 1939], and by the ability of mare serum gonadotrophin to cause ovulation in intact rats but not in hypophysectomized rats [Rowlands & Williams, 1941]. The ineffectiveness of the serum gonadotrophin in causing ovulation in the absence of the pituitary gland of the test animal may be partly explained by its relative lack of luteinizing activity, but it is also certainly caused, in part, by the atrophic condition of the ovaries when the injection is made [Williams, 1943]. Leonard & Smith [1933] observed that in hypophysectomized rats an

This publication has 0 references indexed in Scilit: