Salts of bromine have largely been replaced by phenobarbital and other sedatives in the treatment of epilepsy, and as sedatives in other neurologic conditions. Nevertheless, bromides are still extensively used, particularly in the form of "patent medicines" and nostrums taken for the relief of headache, colds, influenza, and even as laxatives. The untoward effects that not infrequently follow the ingestion of even small amounts of bromide are well known. The lesser evidences of what might be termed bromide intoxication, or bromism, are gastroenteritis, and the less severe types of bromexanthems or bromodermas. Of more serious consequence are occasional definite toxic psychoses and the more severe forms of bromodermas. Of the three halogens, bromine is the most difficult to determine qualitatively in body fluids, especially in the presence of the other two. In a recent study of the experimental aspects of iodide and bromide exanthems, Wile1 showed that in body